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Results for "

Threonyl-tRNA synthetase

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

1

Natural
Products

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-146264
    Antibacterial agent 91

    		Aminoacyl-tRNA Synthetase Bacterial Infection
    Antibacterial agent 91 (Compound 36b) is a triple-site aminoacyl-tRNA synthetase (aaRS) inhibitor with an IC50 of 2.10 μM against Salmonella enterica threonyl-tRNA synthetase (SeThrRS). Antibacterial agent 91 exhibits antibacterial activities .
    Antibacterial agent 91
  • HY-146265
    Antibacterial agent 92

    		Aminoacyl-tRNA Synthetase Bacterial Infection
    Antibacterial agent 92 (Compound 36k) is a triple-site aminoacyl-tRNA synthetase (aaRS) inhibitor with an IC50 of 0.58 μM against Salmonella enterica threonyl-tRNA synthetase (SeThrRS). Antibacterial agent 92 exhibits antibacterial activities .
    Antibacterial agent 92
  • HY-146263
    ThrRS-IN-3

    		Bacterial Infection
    ThrRS-IN-3 (compound 36j) is a highly potent threonyl-tRNA synthetase (ThrRS) inhibitor, with an IC50 value of 19 nM and a Kd of 34 nM for Salmonella enterica ThrRS. ThrRS-IN-3 has antibacterial activities .
    ThrRS-IN-3
  • HY-139657
    ThrRS-IN-2

    		Others Infection
    ThrRS-IN-2 is a threonyl-tRNA synthetase (ThrRS) inhibitor with an IC50 value of 56.5 ± 3.5 μM.
    ThrRS-IN-2
  • HY-138075
    Obafluorin

    		Antibiotic Bacterial Infection
    Obafluorin is a β-Lactone Antibiotic, that can be produced by Pseudomonas fluorescens ATCC 39502. Obafluorin exhibits antibacterial activity against a range of Gram-positive and Gram-negative bacteria. Obafluorin fully inhibits E. coli threonyl-tRNA synthetase .
    Obafluorin
  • HY-130718
    ThrRS-IN-1

    		Bacterial Infection Cancer
    ThrRS-IN-1 (Compound 30d) is a threonyl-tRNA synthetase (ThrRS) inhibitor with an IC50 of 1.4 µM and a Kd of 1.36 µM against Salmonella enterica ThrRS (SeThrRS). ThrRS-IN-1 simultaneously targets the tRNA Thr and L-threonine binding pockets of ThrRS. ThrRS-IN-1 shows potent antibacterial activities .
    ThrRS-IN-1
  • HY-162072
    PfThrRS-IN-1

    		Parasite Infection
    PfThrRS-IN-1 (compound 11) is a potent inhibitor of Plasmodium falciparum threonyl tRNA synthetase (PfThrRS), with the IC50 value of 0.1 μM. PfThrRS-IN-1 is a potent antimalaria agent .
    PfThrRS-IN-1
  • HY-N6742
    Borrelidin
    1 Publications Verification

    Treponemycin

    		 CDK Parasite Apoptosis Antibiotic Infection
    Borrelidin (Treponemycin) is a bacterial and eukaryal threonyl-tRNA synthetase inhibitor which is a nitrile-containing macrolide antibiotic isolated from Streptomyces rochei . Borrelidin is an inhibitor of Cdc28/Cln2 of the budding yeast, with an IC50 of 24 μM . Borrelidin is a potent angiogenesis inhibitor, with an IC50 of 0.8 nM. Borrelidin induces apoptosis in the tube-forming cells . Borrelidin has strong antimalarial activities, with IC50s of 1.9 nM and 1.8 nM against K1 and FCR3 strains of Plasmodium falciparum, respectively .
    Borrelidin

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